Study of potential applications of derivatives of benzothiazole for its anticancer, antimalarial, antiviral and antitubercular properties.


EOI: 10.11242/viva-tech.01.05.002

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Citation

Dipti D. Gharat,Shashikant D. Ajagekar, Ramesh S. Yamgar, Ajitkumar V.Ingle, "Study of potential applications of derivatives of benzothiazole for its anticancer, antimalarial, antiviral and antitubercular properties.", VIVA-IJRI Volume 1, Issue 6, Article 2, pp. 1-9, 2023. Published by Computer Engineering Department, VIVA Institute of Technology, Virar, India.

Abstract

Heterocyclic compounds exhibiting biological activity is widely established. Since then, a large number of heterocyclic derivatives have been synthesized and are now known to have wide range of essential applications in a variety of domains including medical chemistry. Another heterocyclic bicyclic class of molecules containing benzothiazole moiety has a wide range of therapeutic applications, including those for anthelmintics, anticonvulsants, analgesics, antiviral, antifungal, anticancer, anti-inflammatory, antidiabetic, antileishmanial, antitubercular, antibacterial etc. Since benzothiazole derivatives have a diverse range of pharmacological activity, demonstrating the undeniable interest of this class of compounds and also is a rapidly expanding and more active area of study. In this study we have focussed on the potential applications of benzothiazole functionalized compounds for their antiviral, anticancer, antitubercular and antimalarial properties.

Keywords

Applications, Biological activities, benzothiazole derivatives.

References

  1. G. Maga, S. Gemma, C. Fattorusso, G. A. Locatelli, “Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663”, Biochemistry, 44, 2005, 9637-9644.
  2. V. M. Girijavallabhan, C. Alvarez, F. Bennett, L. Chen, S, Gavalas, Pyrimidine derived HCV replication inhibitors”, Bioorganic & medicinal chemistry letters, 22(17), 2012, 5652-7.
  4. K. Bhagdev and S. Sarkar, “Benzothiazole: As an Antiviral Agent”, medical sciences forum, 2021.
  6. S. A. Halim, S, Khan, A. Khan, A. Wadood et al, “Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening”, Front Chem., 5, 2017, 88.
  8. Y. A. Al-Soud, H. Al-Sa’doni, H. A. Amajaour, N. A. Al-Masoudib, “Synthesis and anti-HIV activity of new N-alkyl-4-nitroimidazoles bearing benzothiazole and benzoxazole backbones”, Zeitschrift für Naturforschung B., 62(4), 2007, 523-8.
  10. N. A. Al-Masoudi, N. N. Jafar, L. J. Abbas, S. J. Baqir, C. Pannecouque, “Synthesis and anti-HIV activity of new benzimidazole, benzothiazole and carbohyrazide derivatives of the anti-inflammatory drug indomethacin” Zeitschrift für Naturforschung B., 66(9), 2011, 953-60.
  12. Kumar, M. Chung, S. M. Enkhtaivan, G. Patel, R. V. Shin, H. S. Mistry, “Molecular Docking Studies and Biological Evaluation of Berberine–Benzothiazole Derivatives as an Anti-Influenza Agent via Blocking of Neuraminidase”, Int. J. Mol. Sci., 22, 2021, 2368.
  14. H. LungKok, R. Gambari,C. HinChui, E. Raymond, S. MingWong et al, “Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines”, Bioorganic & Medicinal Chemistry Volume 16(7), 2008, 3626-3631.
  16. P. D. JawalePatil, K. Bhamidipati, M. G. Damale, J. N. Sangshetti, N. Puvvada et al, “Synthesis of naphthalimide derivatives bearing benzothiazole and thiazole moieties: In vitro anticancer and in silico ADMET study”, Journal of Molecular Structure, 1263, 2022, 133173.
  18. A. Irfan, F. Batool, S. A. Z. Naqvi, A. Islam, S. M. Osman, “Benzothiazole derivatives as anticancer agents”, J Enzyme Inhib Med Chem., 35(1), 2020, 265–279.
  20. A. Kamal, M.N.A. Khan, K. Srinivasa Reddy, Y.V.V. Srikanth, B. Sridhar, “Synthesis, structural characterization and biological evaluation of novel [1,2,4] triazolo[1,5-b][1,2,4]benzothiadiazine-benzothiazole conjugates as potential anticancer agents”, Chem. Biol. Drug Des.,71, 2008, 78-86.
  22. P. R. Kadam, Y. D. Bodke, M. D. Naik, O. Nagaraja, B. Manjunatha, “One-pot three-component synthesis of thioether linked 4-hydroxycoumarin-benzothiazole derivatives under ambient condition and evaluation of their biological activity”, Results in Chemistry, 4, 2022, 100303.
  24. I. T. Radwan, A. H. M. Elwahy, A. F. Darweesh, M. Sharaky, N. Bagato, H. F. Khater, M. E. Sale. “Design, synthesis, docking study, and anticancer evaluation of novel bis-thiazole derivatives linked to benzofuran or benzothiazole moieties as PI3k inhibitors and apoptosis inducers”, Journal of Molecular Structure 1265, 2022, 133454.
  26. S. Sarkar “Design, Synthesis, and Evaluation of Antitubercular Activity of Novel Benzothiazole-Containing an Azetidinone Ring”, Istanbul J Pharm, 48 (2), 2018, 28-31.
  28. R. Moodley, C. Mashaba, G.H. Rakodi et al, “New quinoline–urea–benzothiazole hybrids as promising antitubercular agents: synthesis, in vitro antitubercular activity, cytotoxicity studies, and in silico adme profiling”, pharmaceuticals, 15(5), 2022, 576.
  30. N. Nayeem and G. Denny, “Synthesis of some Mannich bases from sulphonamides and benzothiazole derivatives and evaluation of their antitubercular activity and antimicrobial activity”, Scholars Research Library Der Pharma Chemica, 4 (3), 2012, 1277-1282.
  32. S. Khokra, K. Arora, H. Mehta, A. Aggarwal and M. Yadav,” Common methods to synthesize benzothiazole derivatives and their medicinal significance: a review”, IJPSR, 2(6), 2011, 1356-1377.
  34. R. S. Keri, M. R. Patil, S. A. Patil, S. Budagumpi, “A comprehensive review in current developments of benzothiazole based molecules in medicinal chemistry”, European Journal of Medicinal Chemistry, 89, (2015),207-251.
  36. S. Hout, N. Azas, A. Darque, M. Robin, C. Giorgio, M. Gasquet, J. Galy and P. David, “Activity of benzothiazoles and chemical derivatives on Plasmodium falciparum”, Parasitology, 129, 2004, 525-542.
  38. R. Hadanu, S. Idris, and W. Sutapa, “QSAR analysis of benzothiazole derivatives of antimalarial compounds based on AM1 semi-empirical method”, Indones. J. Chem., 15 (1), 2015, 86-92.